Motif ID: HOX{A5,B5}.p2

Z-value: 1.207


Transcription factors associated with HOX{A5,B5}.p2:

Gene SymbolEntrez IDGene Name
HOXA5 3202 homeobox A5
HOXB5 3215 homeobox B5

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HOXA5chr7_-_271497500.273.2e-01Click!
HOXB5chr17_-_44026321-0.019.6e-01Click!


Activity profile for motif HOX{A5,B5}.p2.

activity profile for motif HOX{A5,B5}.p2


Sorted Z-values histogram for motif HOX{A5,B5}.p2

Sorted Z-values for motif HOX{A5,B5}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A5,B5}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_112010233 1.629 NM_001012993
C9orf152
chromosome 9 open reading frame 152
chr7_+_5289079 1.203 NM_001040661
NM_153247
SLC29A4

solute carrier family 29 (nucleoside transporters), member 4

chr3_-_46481346 1.044 NM_002343
LTF
lactotransferrin
chr7_+_45899621 0.917


chr19_-_51168396 0.909 NM_002516
NOVA2
neuro-oncological ventral antigen 2
chr17_+_71109734 0.851 MYO15B
myosin XVB pseudogene
chr17_+_6620275 0.768 NM_153230
FBXO39
F-box protein 39
chr15_-_72804763 0.768 NM_000499
CYP1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
chrX_+_128700605 0.748 NM_003399
XPNPEP2
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
chr1_+_160618143 0.727 NM_001085375
C1orf226
chromosome 1 open reading frame 226
chr1_+_144124547 0.720 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr19_-_56537189 0.707 NM_001163922
VSIG10L
V-set and immunoglobulin domain containing 10 like
chr3_-_51968995 0.652 PCBP4
poly(rC) binding protein 4
chr11_+_66152309 0.648


chr19_-_56919032 0.619 NM_001523
HAS1
hyaluronan synthase 1
chr3_-_42892636 0.576 NM_004391
CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr3_+_185300660 0.557 NM_182589
HTR3E
5-hydroxytryptamine (serotonin) receptor 3, family member E
chr11_-_6633427 0.554 NM_003737
DCHS1
dachsous 1 (Drosophila)
chr10_-_7699192 0.545 ITIH5
inter-alpha (globulin) inhibitor H5
chr14_+_20568184 0.506 NM_173846
TPPP2
tubulin polymerization-promoting protein family member 2
chr10_+_104580420 0.500


chrX_-_111212659 0.486 NM_012471
TRPC5
transient receptor potential cation channel, subfamily C, member 5
chrX_-_104352005 0.469 NM_031274
TEX13A
testis expressed 13A
chr19_+_46207335 0.462 CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr11_-_56905178 0.461 NM_006093
PRG3
proteoglycan 3
chr19_-_51236113 0.457 NM_001002923
IGFL4
IGF-like family member 4
chr8_-_30826074 0.455 NM_031271
TEX15
testis expressed 15
chr22_+_23921072 0.446 KIAA1671
KIAA1671
chr1_-_41259973 0.442 NM_001168247
NM_144990
SLFNL1

schlafen-like 1

chrX_+_51562894 0.440 NM_001005332
MAGED1
melanoma antigen family D, 1
chr18_+_73090913 0.437 NM_001480
GALR1
galanin receptor 1
chrX_+_54851500 0.435 NM_014599
MAGED2
melanoma antigen family D, 2
chrX_+_7147471 0.435 NM_000351
STS
steroid sulfatase (microsomal), isozyme S
chr20_+_2972267 0.420 NM_001501
NM_178331
NM_178332
GNRH2


gonadotropin-releasing hormone 2


chr6_+_31662954 0.419 NM_001166538
NM_007161
NM_205840
LST1


leukocyte specific transcript 1


chr7_+_45894480 0.416 NM_000596
IGFBP1
insulin-like growth factor binding protein 1
chrX_+_48265107 0.412 NM_006579
EBP
emopamil binding protein (sterol isomerase)
chr12_+_6751930 0.412 NM_002286
LAG3
lymphocyte-activation gene 3
chr1_-_159459999 0.411 NM_001643
APOA2
apolipoprotein A-II
chr4_+_109033868 0.411 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chrX_-_139414890 0.410 NM_005634
SOX3
SRY (sex determining region Y)-box 3
chr10_+_122206455 0.410 NM_001030059
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
chr16_-_1971180 0.407 NM_172167
NM_172168
NOXO1

NADPH oxidase organizer 1

chr11_-_59237893 0.405 NM_001005324
OR10V1
olfactory receptor, family 10, subfamily V, member 1
chr19_-_54958326 0.393 NM_021733
TSKS
testis-specific serine kinase substrate
chr5_+_149549712 0.385 NM_014228
SLC6A7
solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
chrX_+_144707022 0.373 NM_001144003
NM_001144004
NM_001144005
NM_032539
SLITRK2



SLIT and NTRK-like family, member 2



chrX_+_48253007 0.373 NM_203474
NM_203475
PORCN

porcupine homolog (Drosophila)

chr8_+_21972804 0.371 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr11_+_36274300 0.370 NM_001160167
PRR5L
proline rich 5 like
chr13_+_57103944 0.364 PCDH17
protocadherin 17
chr9_-_28709302 0.358 NM_152570
LINGO2
leucine rich repeat and Ig domain containing 2
chrX_-_8729377 0.357 NM_001171186
NM_174951
FAM9A

family with sequence similarity 9, member A

chr11_+_20027185 0.357 NAV2
neuron navigator 2
chrX_+_14457340 0.352 NM_001118885
NM_001118886
NM_001171942
NM_002063
GLRA2



glycine receptor, alpha 2



chr3_-_42892195 0.351 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr8_+_21972631 0.349 NM_001114138
NM_001978
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr5_-_35974493 0.346 NM_001042625
NM_144647
CAPSL

calcyphosine-like

chr19_-_47040347 0.344 NM_173506
LYPD4
LY6/PLAUR domain containing 4
chr1_+_148020869 0.344 NM_000566
FCGR1A
Fc fragment of IgG, high affinity Ia, receptor (CD64)
chr3_+_148610516 0.338 ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chrX_-_130251068 0.333 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr17_-_31337798 0.329 NM_032962
NM_032963
CCL14

chemokine (C-C motif) ligand 14

chrX_-_130250880 0.327 IGSF1
immunoglobulin superfamily, member 1
chr8_-_143996257 0.327 NM_000498
CYP11B2
cytochrome P450, family 11, subfamily B, polypeptide 2
chr1_+_202000906 0.326 NM_001136190
NM_017773
LAX1

lymphocyte transmembrane adaptor 1

chrX_-_148394570 0.319 NM_000202
NM_001166550
NM_006123
IDS


iduronate 2-sulfatase


chr20_+_42417502 0.313 HNF4A
hepatocyte nuclear factor 4, alpha
chr11_+_4859624 0.311 NM_001004759
OR51T1
olfactory receptor, family 51, subfamily T, member 1
chr6_-_41114905 0.310 NM_173561
UNC5CL
unc-5 homolog C (C. elegans)-like
chr4_+_152417774 0.309 NM_183375
PRSS48
protease, serine, 48
chr16_-_70168449 0.308 NM_000353
TAT
tyrosine aminotransferase
chr11_+_17714070 0.307 NM_001112741
NM_004976
KCNC1

potassium voltage-gated channel, Shaw-related subfamily, member 1

chr12_-_4358968 0.305 NM_020638
FGF23
fibroblast growth factor 23
chrX_+_114430547 0.304 NM_016383
LUZP4
leucine zipper protein 4
chrX_-_130250715 0.300 NM_001170963
IGSF1
immunoglobulin superfamily, member 1
chr9_-_69468634 0.294 NM_001126334
FOXD4L5
forkhead box D4-like 5
chr13_-_109600709 0.290 COL4A1
collagen, type IV, alpha 1
chr13_+_51334117 0.287 NM_031290
CCDC70
coiled-coil domain containing 70
chr1_-_202595666 0.286 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr1_-_120737416 0.283 FCGR1B
Fc fragment of IgG, high affinity Ib, receptor (CD64)
chr5_-_150501393 0.282 NM_001193544
ANXA6
annexin A6
chrX_+_37777730 0.281 NM_001163334
SYTL5
synaptotagmin-like 5
chrX_+_144136798 0.279 NM_001009614
SPANXN1
SPANX family, member N1
chr1_-_120737466 0.279 NM_001004340
NM_001017986
FCGR1A
FCGR1B

Fc fragment of IgG, high affinity Ia, receptor (CD64)
Fc fragment of IgG, high affinity Ib, receptor (CD64)

chr17_-_44249379 0.278 NM_001130918
TTLL6
tubulin tyrosine ligase-like family, member 6
chr1_-_120189301 0.277 NM_001047980
NBPF7
neuroblastoma breakpoint family, member 7
chr1_+_111215343 0.272 NM_001040033
CD53
CD53 molecule
chr1_-_143706300 0.269 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
PDE4DIP




phosphodiesterase 4D interacting protein




chr12_-_6668680 0.269 ZNF384
zinc finger protein 384
chrX_+_102770303 0.268 NM_001006640
TCEAL1
transcription elongation factor A (SII)-like 1
chrX_+_148433970 0.268 NM_001171909
CXorf40A
chromosome X open reading frame 40A
chr1_+_147006065 0.267 NM_001102663
NBPF15
NBPF8
NBPF16
neuroblastoma breakpoint family, member 15
neuroblastoma breakpoint family, member 8
neuroblastoma breakpoint family, member 16
chr1_+_148511806 0.266 NM_024579
C1orf54
chromosome 1 open reading frame 54
chrX_+_102770547 0.265 NM_001006639
NM_004780
TCEAL1

transcription elongation factor A (SII)-like 1

chr13_+_113574925 0.264 NM_001143945
GAS6
growth arrest-specific 6
chrX_-_152863251 0.264 NM_002910
RENBP
renin binding protein
chrX_-_135166306 0.263 NM_001173516
MAP7D3
MAP7 domain containing 3
chr3_+_11009419 0.263 NM_003042
SLC6A1
solute carrier family 6 (neurotransmitter transporter, GABA), member 1
chr1_-_154041393 0.262 GON4L
gon-4-like (C. elegans)
chr17_-_33753218 0.262 NM_001004334
GPR179
G protein-coupled receptor 179
chr1_+_154386358 0.260 NM_001193301
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr15_+_22772545 0.259 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr10_+_102285690 0.259 HIF1AN
hypoxia inducible factor 1, alpha subunit inhibitor
chrX_-_99778340 0.259 NM_003270
TSPAN6
tetraspanin 6
chrX_-_64112993 0.258 NM_001178033
NM_018684
ZC4H2

zinc finger, C4H2 domain containing

chr1_+_158352143 0.258 NM_000702
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr19_-_53444733 0.257 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr14_+_60045621 0.257 NM_007374
SIX6
SIX homeobox 6
chrX_+_134895447 0.256 SLC9A6
solute carrier family 9 (sodium/hydrogen exchanger), member 6
chr12_+_26096757 0.256 NM_001164746
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr15_-_49184764 0.256 NM_207381
TNFAIP8L3
tumor necrosis factor, alpha-induced protein 8-like 3
chr1_-_143706196 0.254 PDE4DIP
phosphodiesterase 4D interacting protein
chr1_-_120240635 0.254 NM_021794
ADAM30
ADAM metallopeptidase domain 30
chr12_+_6800950 0.253 NM_014449
NM_019858
GPR162

G protein-coupled receptor 162

chrX_-_107112244 0.253 NM_031273
TEX13B
testis expressed 13B
chrX_+_103297891 0.253 NM_207318
FAM199X
family with sequence similarity 199, X-linked
chr1_-_20318578 0.253 NM_012400
PLA2G2D
phospholipase A2, group IID
chr19_+_40824486 0.252 NM_014209
ETV2
ets variant 2
chr9_+_42707229 0.252 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chr1_+_146843980 0.250 NM_001102663
NBPF15
NBPF8
NBPF16
neuroblastoma breakpoint family, member 15
neuroblastoma breakpoint family, member 8
neuroblastoma breakpoint family, member 16
chr19_-_63550712 0.248 A1BG
alpha-1-B glycoprotein
chr1_+_152567843 0.248 ATP8B2
ATPase, class I, type 8B, member 2
chr22_+_18388656 0.248 C22orf25
chromosome 22 open reading frame 25
chr1_-_36338436 0.247 NM_005202
COL8A2
collagen, type VIII, alpha 2
chr8_-_55097533 0.247 NM_006756
NM_201437
TCEA1

transcription elongation factor A (SII), 1

chr9_-_69669550 0.246 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chr11_-_117600918 0.245 NM_001098526
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr22_+_19651446 0.245 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr1_+_143326315 0.242 NM_001037675
NBPF10
NBPF9
NBPF8
neuroblastoma breakpoint family, member 10
neuroblastoma breakpoint family, member 9
neuroblastoma breakpoint family, member 8
chr10_+_50487146 0.239 NM_020984
CHAT
choline O-acetyltransferase
chr11_-_8911110 0.239 NM_020643
C11orf16
chromosome 11 open reading frame 16
chr1_+_146827470 0.238 NM_173638
NBPF15
neuroblastoma breakpoint family, member 15
chrX_+_96025562 0.237 NM_013347
RPA4
replication protein A4, 30kDa
chr2_+_102136833 0.235 NM_000877
IL1R1
interleukin 1 receptor, type I
chr17_-_3321782 0.232 NM_032598
NM_001170699
NM_001170698
NM_001170697
NM_001170695
NM_001170696
SPATA22





spermatogenesis associated 22





chr22_+_18388633 0.228 C22orf25
chromosome 22 open reading frame 25
chr22_+_28206180 0.228 NM_021076
NEFH
neurofilament, heavy polypeptide
chr19_+_62434188 0.226 NM_001015879
NM_003160
NM_001015878
AURKC


aurora kinase C


chr16_+_29728932 0.226 MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr1_-_159459814 0.226 APOA2
apolipoprotein A-II
chr1_+_116717404 0.225 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr14_-_94053933 0.224 NM_173850
SERPINA12
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
chr7_+_156128431 0.224 NM_001184997
RNF32
ring finger protein 32
chr14_+_23852152 0.220 NM_181657
LTB4R
leukotriene B4 receptor
chr4_-_154900599 0.219 RNF175
ring finger protein 175
chrX_-_153290697 0.218 NM_006730
DNASE1L1
deoxyribonuclease I-like 1
chr12_+_48784057 0.218 NM_005276
GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr3_+_11009436 0.217 SLC6A1
solute carrier family 6 (neurotransmitter transporter, GABA), member 1
chr6_-_42270671 0.214 NM_002098
GUCA1B
guanylate cyclase activator 1B (retina)
chr16_-_82633262 0.213 NM_001080442
SLC38A8
solute carrier family 38, member 8
chr13_+_57103789 0.212 NM_001040429
PCDH17
protocadherin 17
chr10_-_30356344 0.212 KIAA1462
KIAA1462
chr10_+_102285562 0.211 NM_017902
HIF1AN
hypoxia inducible factor 1, alpha subunit inhibitor
chr1_-_180297372 0.211 NM_001009992
ZNF648
zinc finger protein 648
chr5_-_35083996 0.210 NM_031900
AGXT2
alanine--glyoxylate aminotransferase 2
chrX_-_23955223 0.209 NM_030624
KLHL15
kelch-like 15 (Drosophila)
chr1_+_32703225 0.209 NM_001145720
ZBTB8B
zinc finger and BTB domain containing 8B
chr1_+_174698929 0.207 NM_020318
NM_021936
PAPPA2

pappalysin 2

chr11_+_75106512 0.207 NM_025098
MOGAT2
monoacylglycerol O-acyltransferase 2
chr22_-_39966801 0.206 NM_138481
CHADL
chondroadherin-like
chr17_-_7107229 0.204 NM_001185022
CLDN7
claudin 7
chrX_-_137777382 0.203 NM_001139502
FGF13
fibroblast growth factor 13
chr8_-_22841173 0.202 NM_144962
PEBP4
phosphatidylethanolamine-binding protein 4
chr1_-_143706265 0.202 PDE4DIP
phosphodiesterase 4D interacting protein
chr3_-_135131207 0.201 NM_025041
C3orf36
chromosome 3 open reading frame 36
chr3_-_122862447 0.200 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr22_-_35835548 0.198 TMPRSS6
transmembrane protease, serine 6
chr1_-_109853808 0.198 NM_020703
AMIGO1
adhesion molecule with Ig-like domain 1
chr22_-_49363711 0.195 NM_004377
NM_152246
NM_001145134
NM_001145135
NM_001145136
NM_152245
CPT1B





carnitine palmitoyltransferase 1B (muscle)





chr9_-_14769530 0.195 NM_001177704
FREM1
FRAS1 related extracellular matrix 1
chr14_-_93914634 0.193 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr11_-_125055884 0.192 NM_001612
NM_020069
NM_020107
NM_020108
NM_020109
NM_020110
NM_020111
NM_020113
NM_020115
ACRV1








acrosomal vesicle protein 1








chrX_-_131375217 0.192 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr15_-_41728329 0.191 NM_054020
NM_172095
NM_172097
CATSPER2


cation channel, sperm associated 2


chrX_+_102498035 0.191 NM_001006612
NM_001006613
NM_001006614
NM_016303
WBP5



WW domain binding protein 5



chrX_-_52403720 0.190 NM_130777
XAGE2
X antigen family, member 2
chr1_-_150805852 0.190 NM_178435
LCE3E
late cornified envelope 3E
chr11_+_10480891 0.190 AMPD3
adenosine monophosphate deaminase 3
chr16_+_68516401 0.189 NM_199424
WWP2
WW domain containing E3 ubiquitin protein ligase 2
chrX_+_149612488 0.189 NM_003828
MTMR1
myotubularin related protein 1
chr9_+_70107602 0.188 NM_199135
FOXD4L3
FOXD4L6
forkhead box D4-like 3
forkhead box D4-like 6
chr1_-_71319559 0.188 NM_005455
NM_203350
ZRANB2

zinc finger, RAN-binding domain containing 2

chrX_-_151037066 0.187 NM_021049
MAGEA5
melanoma antigen family A, 5
chr1_-_90955365 0.187 NM_020063
BARHL2
BarH-like homeobox 2
chr11_+_72660894 0.187 NM_004154
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr9_+_137107007 0.187 OLFM1
olfactomedin 1
chr12_-_6668787 0.186 NM_001039918
NM_133476
ZNF384

zinc finger protein 384

chr1_+_20385164 0.185 NM_152376
UBXN10
UBX domain protein 10
chr1_-_151679126 0.184 NM_001045479
S100A7L2
S100 calcium binding protein A7-like 2
chr1_-_155336223 0.184 NM_001004341
ETV3L
ets variant 3-like
chr3_+_63403792 0.183 NM_144642
SYNPR
synaptoporin
chr14_-_63079299 0.183 PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr14_+_95222506 0.182 NM_004918
NM_199206
TCL1B

T-cell leukemia/lymphoma 1B

chr16_-_1971360 0.181 NM_144603
NOXO1
NADPH oxidase organizer 1
chr12_-_118725672 0.180 CIT
citron (rho-interacting, serine/threonine kinase 21)
chr1_-_23683214 0.180 ASAP3
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
chr19_-_7598204 0.180 XAB2
XPA binding protein 2
chr16_-_48960186 0.180 NM_001173984
NM_013263
BRD7

bromodomain containing 7

chr11_+_125208420 0.180 NM_001144874
PATE4
prostate and testis expressed 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
11.18 5.13e-03 GO:0060678 dichotomous subdivision of terminal units involved in ureteric bud branching
9.94 1.45e-02 GO:0048880 sensory system development
9.94 1.45e-02 GO:0048892 lateral line nerve development
9.94 1.45e-02 GO:0048895 lateral line nerve glial cell differentiation
9.94 1.45e-02 GO:0048925 lateral line system development
9.94 1.45e-02 GO:0048937 lateral line nerve glial cell development
9.94 1.45e-02 GO:0050935 iridophore differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.23 3.83e-03 GO:0005886 plasma membrane
1.23 5.27e-03 GO:0071944 cell periphery
1.31 2.05e-02 GO:0044459 plasma membrane part

Nothing significant found in function category.